Have you had genetic tests? I have no Cyp2d6. Clinical pharmacologist told me fentanyl and morphine would work on me. Oxy does nothing.
I highly suggest people try asking questions to an AI program . I use Elon musk’s Grok . When I plugged in the info for this poster it gave answers as to what might work and why . After surgery is more complicated . I need a different major surgery and have been putting it off. I can’t use fentanyl for 90 days because it seems likely I would get addicted .
I haven’t run that question through for me yet although I did ask it how missing this enzyme might cause problems with toxins building in my head since my drainage is compromised. Gave me thorough answer
Grok did say that people with mcas may have heightened pain perception and those people may need multi modal approach . Gave a lot of info that you have to tailor to ones personal situation as you ask the questions