Hi, I came across this article that maybe useful for those on this forum that have persistant non-pulsatile tinnitus after internal jugular vein decompression surgery. It might be worthwhile researching a bit more into the use of PEA and luteolin which are both anti-neuroinflammatory agents.
PEA seems particularly interesting as it is naturally produced by the body when there is inflammation and it is not a COX-2 inhibitor either (unlike NSAIDS) so it doesn’t interfer with the production of resolvins which are also naturally produced by the body to resolve and clean up inflammation ie after a surgical procedure. Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
Resolution of inflammation: state of the art, definitions and terms
@TheDude mentioned the use of PEA back in 2023 for neuropathic pain Palmitoylethanolamide (PEA): A Natural Compound for Health Management - Has anyone experience with PEA already?
I questioned AI a little bit on PEA for those who are wary of supplements. Below is a summary :
PEA (palmitoylethanolamide) is an anti neuroinflammatory agent used in non-pulsatile tinnitus studies linked to vascular anomalies (2025). Supplements of PEA have been used in nerve pain and neuroinflammation such as multiple sclerosis, neuropathy and nerve pain.
PEA is produced naturally by the body when there is inflammation. It acts by binding to PPAR-alpha which reduces the activation of microglia and mast cells.
The precursor of PEA is palmitic acid (a saturated fat) which is a major component of pork fat, dairy fats, chicken skin, turkey skin, and tropical oils such as palm oil. Best sources are palm oil 49%, pork fat (25-30%), butter 29%, cocoa butter (chocolate) 25%.
Best sources when trying to avoid an increase in bad cholesterol and their effect on the cardiovascular system are avocadoes, avocado oil (10-12% palmitic acid and 60-70% oleic acid. The later offsets the bad effects on LDL cholesterol of palmitic acid) and moderate intakes of dairy and pork fat, turkey skin and chicken skin.
Unrefined red palm oil (RSPO, an environmental label) contains 44% palmitic acid and 39-40% oleic acid. Why “Unrefined” Matters: The “red” in red palm oil comes from high levels of carotenoids (like beta-carotene) and tocotrienols (Vitamin E). These are present in the unrefined state but are largely removed during the refining, bleaching, and deodorizing (RBD) process used to make the oil colorless and odorless for mass market products. While the fatty acid percentages (oleic vs. palmitic) remain relatively similar between refined and unrefined versions, the unrefined oil retains the antioxidants that may help mitigate the oxidative stress associated with higher saturated fat intake.
