I’m pretty sure that it’s been mentioned that there can be long term neurological effects of IJV compression, and possibly being linked to dementia, but I can’t find any actual research papers to confirm it, if you Google this question the answer is
’ Intracranial hypertension can contribute to cognitive decline and dementia, primarily through its association with vascular damage and neuroinflammation.
Understanding Intracranial Hypertension
Intracranial hypertension refers to increased pressure within the skull, which can result from various conditions, including head injury, tumors, or idiopathic intracranial hypertension. This elevated pressure can lead to damage to brain structures and affect cognitive function.’
But the links to explanations for this all then talk about increased blood pressure rather than intracranial hypertension. But I think it stands to reason that this increased pressure can lead to inflammation, can inhibit waste removal (which the CSF does) so could build toxins up, and perhaps damages blood vessels long term. There are a couple of research papers which you might be interested in:
Cerebral Venous-Associated Brain Damage May Lead to Anxiety and Depression - General / Research Papers - Living with Eagle
This article by Kjetil Larsen mentions effects of intracranial hypertension:
View of Does thoracic outlet syndrome cause cerebrovascular hyperperfusion? Diagnostic markers for occult craniovascular congestion | Anaesthesia, Pain & Intensive Care
FARGEN; HUI et al. (2025) - Cerebral venous outflow revisited: Contemporary insights to simplify a complex disease - General / Research Papers - Living with Eagle