If you ask me, the implication is big. As our Jugular Veins (the main clearance pathway) remain impaired, one can hypothesize that our toxic and metabolic clearance is impacted. The degree to which it is impacted might differ depending on the severity of compression and the robustness of the collateral drainage etc. BTW, there are studies linking IJVS/impaired venous outflow to Alzheimer’s disease. One pathway that is gaining popularity is glymphatic pathway.
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